(OTCBB: ACTC)
A biotechnology company focused on applying stem cell technology in the field of regenerative medicine to bring effective, patient-specific therapies to the bedside
Advanced Cell Technology

Advanced Cell Technology's Executive Invited to Present Today to FDA Advisory Committee on Cellular Tissue Therapies

Advanced Cell Technology, Inc. (OTCBB: ACTC) announced today that Jonathan H. Dinsmore Ph.D., Senior Vice President – Regulatory and Clinical, has been invited to present to the U.S. Food and Drug Administration’s Center for Biologics Evaluation and Research Advisory Committee on Cellular, Tissue and Gene Therapies. Dr. Dinsmore will deliver a presentation today titled, “Safety Considerations for the Clinical Application of Human Embryonic Stem Cells” to the FDA panel, which will convene at the Hilton Hotel in Gaithersburg, Maryland. The presentation is scheduled for 10 a.m. eastern time. The panel is expected to conduct hearings on Cellular Therapies Derived from Human Embryonic Stem Cells Scientific Considerations for Pre-Clinical Safety Testing. Other companies invited to present include Geron Corporation (NASDAQ: GERN) and Novocell, Inc.



During Dr. Dinsmore’s presentation, he is expected to discuss cell sourcing, manufacturing and delivery of human embryonic stem cells. He will also present certain conclusions from pre-clinical activities surrounding the company’s retinal pigmented epithelial (RPE) cell therapy. Advanced Cell recently completed discussions with the FDA regarding this program through a type B, pre-Investigational New Drug (pre-IND) meeting concerning the regulatory pathway and requirements to file an IND to initiate human clinical trials. The entire presentation will be available on the company’s web site at www.advancedcell.com/conference-presentations after 11 a.m. eastern time today.

“We are honored that the FDA has invited us to participate in this panel, which could be influential in shaping the clinical pathway for the testing of embryonic stem cells,” said William M. Caldwell IV, Chairman and CEO of Advanced Cell Technology, Inc. “As one of the few stem cell companies that is preparing for later-stage clinical trials, we are pleased that we will be able to share our views with FDA executives and other distinguished members of the scientific community on the safety issues surrounding human embryonic stem cell development.”

Additional details on the FDA meeting may be found at www.fda.gov/ohrms/dockets/ac/cber08.html#CellularTissueGene Therapies (Due to its length, this URL may need to be copied/pasted into your Internet browser's address field. Remove the extra space if one exists). 

About Advanced Cell Technology, Inc.

Advanced Cell Technology, Inc. is a biotechnology company applying cellular technology in the emerging field of regenerative medicine. The company operates facilities in California and Massachusetts.

For more information, visit www.advancedcell.com  

Forward-Looking Statements

Statements in this news release regarding future financial and operating results, future growth in research and development programs, potential applications of our technology, opportunities for the company and any other statements about the future expectations, beliefs, goals, plans, or prospects expressed by management constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Any statements that are not statements of historical fact (including statements containing the words "will," "believes," "plans," "anticipates," "expects," "estimates," and similar expressions) should also be considered to be forward-looking statements. There are a number of important factors that could cause actual results or events to differ materially from those indicated by such forward-looking statements, including: limited operating history, need for future capital, risks inherent in the development and commercialization of potential products, protection of our intellectual property, and economic conditions generally. Additional information on potential factors that could affect our results and other risks and uncertainties are detailed from time to time in the company's periodic reports, including the report on Form 10-QSB for the quarter ended September 30, 2007. Forward-looking statements are based on the beliefs, opinions, and expectations of the company's management at the time they are made, and the company does not assume any obligation to update its forward-looking statements if those beliefs, opinions, expectations, or other circumstances should change.

Forward-looking statements are based on the beliefs, opinions, and expectations of the company's management at the time they are made, and the company does not assume any obligation to update its forward-looking statements if those beliefs, opinions, expectations, or other circumstances should change.

CEOcast, Inc. for Advanced Cell Technology
Daniel Schustack, 212-732-4300


Source: Business Wire (April 10, 2008 - 9:23 AM EDT)

Advanced Cell Technology Platform Yields Over 140 Cell Types from Human Embryonic Stem Cells

Advanced Cell Technology, Inc. (OTCBB: ACTC; www.advancedcell.com) reported today on a large-scale differentiation process that has generated panels of differentiating human progenitor cell lines from human embryonic stem cells (hESCs). The research will be published in the April issue of Regenerative Medicine (Vol. 3[3] e-pub ahead of print) and will be freely available at www.futuremedicine.com/loi/rme. << MORE >>

Barbara Walters' ABC Network Television Special Highlights Role that Advanced Cell Technology's Embryonic Stem Cells Play in Preventing Aging

Advanced Cell Technology, Inc. (OTCBB: ACTC) announced today that an ABC Television’s special report titled, “Live to 150, Can You Do It? Secrets to Living Longer,” which aired last night and was hosted by Barbara Walters, highlighted the role that the company’s blastomere program for creating human embryonic stem cell (hESC) lines without impacting the developmental potential of embryos could play in extending life and slowing down the aging process. The special also highlighted Advanced Cell Technology’s research into developing a universal O negative red blood cell bank using human embryonic stem cell science. The report, which included an interview with Dr. Robert Lanza, MD, Chief Scientific Officer at Advanced Cell Technology, featured the company’s research platforms and included a discussion of the role that the company’s stem cell science could play in treating various diseases. << MORE >>

Advanced Cell Technology to be Featured Tonight on ABC Television's Special Report ''Live to 150, Can You Do It? Secrets to Living Longer''

Advanced Cell Technology, Inc. (OTCBB: ACTC) announced today that the company will be featured on ABC Television’s special report titled, “Live to 150, Can You Do It? Secrets to Living Longer,” hosted by Barbara Walters. The report is scheduled to air tonight on ABC Television throughout the country at 10 PM eastern time. The report will include an interview with Dr. Robert Lanza, MD, Chief Scientific Officer at Advanced Cell Technology. During the interview, Dr. Lanza and Ms. Walters will discuss a number of Advanced Cell Technology’s research platforms including its blastomere program for creating human embryonic stem cell (hESC) lines without impacting the developmental potential of embryos as well as the company’s research into developing a universal O negative red blood cell bank using human embryonic stem cell science. << MORE >>

Advanced Cell Technology Completes Private Placement

Advanced Cell Technology, Inc. (OTCBB:ACTC) announced today that it completed a private placement with institutional and other accredited investors. The company intends to use the proceeds of the offering towards for general corporate purposes, including additions to working capital, and to finance the further development of the company’s clinical programs. << MORE >>

Advanced Cell Technology Announces Catheter Supply Agreement with Biologics Delivery Systems Group

Advanced Cell Technology, Inc. (OTCBB: ACTC) announced today that it has reached a supply agreement with Biologics Delivery Systems Group, Cordis Corporation (a Johnson & Johnson company), in which Biologics Delivery Systems will supply catheters for the Phase II human clinical trial of ACT’s myoblast therapy for the treatment of heart failure. Advanced Cell Technology’s myoblast therapy successfully completed Phase I human clinical trials in 2007 utilizing the therapy safely in more than forty patients. Safety of the therapy was demonstrated in four independent studies. The U.S. Food and Drug Administration has given the company clearance to proceed with Phase II human clinical trials. The company expects its Phase II human clinical trial (CAuSMIC II) to begin shortly. << MORE >>

Advanced Cell Technology, Inc. Enters into License Agreement with Pharming Group N.V.

Company Continues to Leverage IP Portfolio Advanced Cell Technology, Inc. (OTCBB:ACTC) announced today that it has entered into an agreement with Pharming Group N.V. giving Pharming an exclusive, global license to non-human use of certain patents associated with but not limited to oocyte activation patents held by Advanced Cell Technology. According to the terms of the license agreement, Pharming will pay Advanced Cell Technology a one-time license fee. Prior, Pharming had a nonexclusive license to these patents. Based in the Netherlands, Pharming Group N.V. is focused on developing treatments for genetic and aging diseases, specialty products for surgical indications, and intermediates for various applications and nutritional products. << MORE >>

Advanced Cell Technology Demonstrates Efficient Generation of Functional Hepatocytes (Liver Cells) From Human Embryonic Stem Cells

Company Makes Progress on Multiple Therapeutic Fronts Advanced Cell Technology, Inc. (OTCBB: ACTC) reported today for the first time a robust and highly efficient process for the generation of high-purity hepatocytes (liver cells). The research, described online (ahead of print) in the journal STEM CELLS, signifies a significant step towards the efficient generation of hepatocytes for use in regenerative medicine and drug discovery. Moreover, the research represents another one of Advanced Cell Technology’s efforts aimed at the large-scale differentiation of human embryonic stem cells (hESCs) into critical replacement cell types. In addition to demonstrating the efficient generation of hepatocytes in research published today, the company has made significant progress in the generation of retinal pigmented epithelial (RPE) cells to treat retinal degenerative diseases and the generation of hemangioblasts to treat vascular disease as well as to create a large-scale and donorless source of red blood cells and platelets. << MORE >>

Advanced Cell Technology Announces Presentation of Results from Myoblast Study at ISCTR World Symposium

Study Results Demonstrate Long Term Cell Survival and Quality of Life Improvements Advanced Cell Technology, Inc. (OTCBB: ACTC - News) announced today that principal investigator Dr. Nabil Dib, M.D., M.Sc., FACC, presented results from a 23-patient study of ACT’s myoblast therapy for the treatment of congestive heart failure (CHF) over the weekend at the International Society for Cardiovascular Translational Research (ISCTR) World Symposium in San Diego, CA. Dr. Dib presented the results as a case study of the successful translation of a therapy from scientific research to the bedside. The results of the study demonstrate long term cell survival in heart failure patients as well as strong quality of life improvements as measured by the New York Heart Association third party questionnaire, the Minnesota Living with Heart Failure Questionnaire, and the 6 minute walk results (compared to continued deterioration by the control group). Moreover, ACT’s myoblast trial has been the only cell-based, FDA-approved human clinical trial that has not required the administration of anti-arrhythmic drugs or assist devices, which is in contrast to trials for bone marrow-derived and other adult stem cell therapies. << MORE >>

Advanced Cell Technology Announces Completion of Pre-IND Meeting with the FDA for RPE Therapy for the Treatment of Retinal Degenerative Disease

Company Demonstrates Progress Toward Moving its Second Cell Therapy into Human Clinical Trials Advanced Cell Technology, Inc. (OTCBB:ACTC) today announced that it completed discussions with the Food and Drug Administration (FDA) regarding its retinal pigmented epithelial (RPE) cell therapy through a type B, pre-Investigational New Drug (pre-IND) meeting concerning the regulatory pathway and requirements to file an IND to initiate human clinical trials. ACT is working with the agency to fulfill the FDA’s requirements to bring its RPE cell therapy into human clinical trials for the treatment of retinal degenerative diseases such as Retinitis Pigmentosa, Stargardt’s disease, and dry age-related macular degeneration (AMD). The RPE cells are derived from human embryonic stem cells created from ACT single blastomere cell lines under GMP compliant conditions. ACT is moving forward with its characterized RPE manufacturing process to complete the final stages of the company’s preclinical testing. Should ACT successfully file an IND for its RPE therapy, the company plans to move forward with Phase I human clinical trials. ACT’s Myoblast therapy, an autologous adult stem cell therapy for the treatment of heart failure, has already successfully completed Phase I human clinical trials and is moving into Phase II human clinical trials shortly. << MORE >>